Dibenzazepine (YO-01027) CAS:209984-56-5

Yo-01027 is a dipeptide type γ-secretase inhibitor with IC50 of 2.6 nm and 2.9 nm,respectively.Yo-01027 is an anti Alzheimer drug.Yo-01027 interacts directly with γ-secretase complex.Different from other γ-secretase inhibitors,yo-01027 targets different functional domains of the complex.Yo-01027 targets the N-terminal presenilin fragment and another gamma secretase inhibitor compound E(CPN E),while dfk167 and dapt bind to the catalytic sites of presenilin aspartate protease subunit and C-terminal presenilin fragment,respectively.In one study,yo-01027 and cpne showed no significant difference in blocking appl and notch cleavage,indicating that the IC50 values of the two substrates were statistically equal.

msds---Dibenzazepine (YO-01027)